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The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
- Weinhold, Niels (author)
- Johnson, David C. (author)
- Chubb, Daniel (author)
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- Chen, Bowang (author)
- Hosking, Fay J. (author)
- Broderick, Peter (author)
- Ma, Yussanne P. (author)
- Dobbins, Sara E. (author)
- Hose, Dirk (author)
- Walker, Brian A. (author)
- Davies, Faith E. (author)
- Kaiser, Martin F. (author)
- Li, Ni L. (author)
- Gregory, Walter A. (author)
- Jackson, Graham H. (author)
- Witzens-Harig, Mathias (author)
- Neben, Kai (author)
- Hoffmann, Per (author)
- Noethen, Markus M. (author)
- Muehleisen, Thomas W. (author)
- Eisele, Lewin (author)
- Ross, Fiona M. (author)
- Jauch, Anna (author)
- Goldschmidt, Hartmut (author)
- Houlston, Richard S. (author)
- Morgan, Gareth J. (author)
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- (creator_code:org_t)
- 2013-03-17
- 2013
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:5, s. 522-525
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- Weinhold, Niels
- Johnson, David C ...
- Chubb, Daniel
- Chen, Bowang
- Försti, Asta
- Hosking, Fay J.
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- Broderick, Peter
- Ma, Yussanne P.
- Dobbins, Sara E.
- Hose, Dirk
- Walker, Brian A.
- Davies, Faith E.
- Kaiser, Martin F ...
- Li, Ni L.
- Gregory, Walter ...
- Jackson, Graham ...
- Witzens-Harig, M ...
- Neben, Kai
- Hoffmann, Per
- Noethen, Markus ...
- Muehleisen, Thom ...
- Eisele, Lewin
- Ross, Fiona M.
- Jauch, Anna
- Goldschmidt, Har ...
- Houlston, Richar ...
- Morgan, Gareth J ...
- Hemminki, Kari
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- MEDICAL AND HEALTH SCIENCES
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- Lund University
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